Sialadenitis in IQILJic Mice : A New Animal Model of sy 6 gren ' s Syndrome
نویسنده
چکیده
age. Infiltrating lyrnphecytes consisted of both T and B cells, 'lhe dominant lymphecytes in small foci were CD4' ce]ls, but the majority of infiltrating ce]ls were B cells (B220'), foltowed by CD4' T cells in larger lesions, The ductual epithelium in the foci aberrantly expressed MHC class Il antigen. Eight ef 24 15-month-o]d female mice with siatadenitis produced speckled-type IgG antinuclear autountibody, These findings are similar te those in patients with SjOgren's syndrome. IQIiJic mice eould be a nove] animal model of Sj6gren's syndrome. KEy woRDs/ anima] mode], IQIIJic, sialadenitis, Sjt5gren's syndiome.
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